investigation of cosenza mutation in patients with deficiency of glucose-6-phosphate dehydrogenase (g6pd) in north west of iran
نویسندگان
چکیده
glucose-6-phosphate dehydrogenase (g6pd) is a greatly polymorphic enzyme encoded by human x-linked gene. g6pd deficit is the most public enzymopathy in human with about 400 million people affected globally. it is the main controlling enzyme in the hexose monophosphate shunt catalase the oxidation of glucose-6-phosphate to 6-phosphogluconolacton and the creation of reducing equals in the form of nadph to meet the cellular redox formal and its absence origin hemolytic anemia - favism and newborn jaundice. mutation in this enzyme cause three major types of unusual phenotype, including mediterranean, chatham and cosenza. in this study, by rapid genomic dna extraction (rgde) method, from 90 blood samples of unrelated male and female patients with genetic deficiency of g6pd, dna was removed and next digestion by eco81i enzymes, in order to research for cosenza mutation, they were analyzed by means of pcr-rflp. sequencing methods were used. of 90 patients, one patient had a cosenza mutation frequency of 1.01%. eighty-nine patients (98.99%) were not affected by the cosenza-type mutation. accordingly, cosenza mutation is not regarded as the most common mutation in iranian north-west population.
منابع مشابه
Molecular Characterization of Cosenza Mutation among Patients with Glucose-6-Phosphate Dehydrogenase Deficiency in Khuzestan Province, Southwest Iran
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common hereditary enzymatic disorders in human, increases the vulnerability of erythrocytes to oxidative stress. It is also characterized by remarkable molecular and biochemical heterogeneity. According to previous investigations, G6PD Cosenza (G1376C) is a common G6PD mutation in some parts of Iran. Therefore in the present...
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متن کاملmolecular characterization of cosenza mutation among patients with glucose-6-phosphate dehydrogenase deficiency in khuzestan province, southwest iran
glucose-6-phosphate dehydrogenase (g6pd) deficiency is one of the most common hereditary enzymatic disorders in human, increases the vulnerability of erythrocytes to oxidative stress. it is also characterized by remarkable molecular and biochemical heterogeneity. according to previous investigations, g6pd cosenza (g1376c) is a common g6pd mutation in some parts of iran. therefore in the present...
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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common hereditary enzymatic disorders in human, increases the vulnerability of erythrocytes to oxidative stress. It is also characterized by remarkable molecular and biochemical heterogeneity. According to previous investigations, G6PD Cosenza (G1376C) is a common G6PD mutation in some parts of . Therefore in the present stu...
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عنوان ژورنال:
journal of chemical health risksجلد ۵، شماره ۱، صفحات ۰-۰
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